4,1',6'-Trideoxy-4,1',6'-trichloro-Sucrose, X-Ray (left) and PIMM88-Structure (right). Both models differ mainly in the directionality of the 2-O ... HO-3' intramolecular interresidue hydrogen bond.

mep1	mep2	mlp1	mlp2
cut1	cut2	cut3	cut4	cut5	cut6

Image Notes
mep1,2	Molecular electrostatic potential profile (MEP, red: positive, violet: negative potentials), AM1 atomic charges
mlp1,2	Molecular lipophilicity pattern (MLP, yellow-brown: hydrophobic, blue: hydrophilic areas)
cut1-6	Iso-potential cuts of the molecular surface (PIMM88-structure only) sliced along constant potentials to identify the hydrogen bond donor (AH) unit (MEP > +12.0 kcal/mol, red), the H-bond acceptor (B) portion (MEP < -12.0 kcal/mol, blue or green), and the hydrophobic binding region X (yellow-brown, MLP > 0.04) as the AH-B-X-system of sweetness. The large blue surface section represents the most hydrophilic molecular region (dark blue, MLP < -0.002) encompassing the AH-B-couple.

For details see:

Molecular Modeling of Saccharides, Part III. Sucrose, Sucralose, and Fructose: Correlations Between Hydrophobicity Potential Profiles and AH-B-X Assignments. F. W. Lichtenthaler and S. Immel, in: Sweet Taste Chemoreception (Eds.: M. Mathlouthi, J. A. Kanters, and G. G. Birch), Elsevier Appl. Science, London/New York, 1993, pp. 21-53.
Abstract

Cyclamate, Saccharine, Acesulfame, Aspartame, and a Retro-Inverso-Sweetener

Cyclamat, Saccharine, and Acesulfame
sld	mep1	mep2	mlp1	mlp2
Aspartame and a Retro-Inverso-Sweetener
sld	mep1	mep2	mlp1	mlp2
Aspartame
sld	mep1	mep2	mlp1	mlp2

Image Notes
sld	Molecular surfaces - all solid-state structures
mep	Molecular electrostatic potential profiles (MEP, red: positive, violet: negative potentials), AM1 atomic charges
mlp	Molecular lipophilicity patterns (MLP, yellow-brown: hydrophobic, blue: hydrophilic areas)

For details see:

Molecular Modeling of Saccharides, Part III. Sucrose, Sucralose, and Fructose: Correlations Between Hydrophobicity Potential Profiles and AH-B-X Assignments. F. W. Lichtenthaler and S. Immel, in: Sweet Taste Chemoreception (Eds.: M. Mathlouthi, J. A. Kanters, and G. G. Birch), Elsevier Appl. Science, London/New York, 1993, pp. 21-53.
Abstract