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Proceedings of the Eighth International Symposium on Cyclodextrins

Proceedings of the 8th Internat. Symposium on CDs

The cover illustration displays α-cyclodextrin with its MOLCAD program generated contact surface, onto which the molecular lipophilicity patterns (MLPs) are projected in a color-code ranging from blue (hydrophilic regions) to yellow (hydrophobic areas). The α-CD donuts (top entries) are viewed through the larger opening of the conically shaped molecule (left), thereby exposing the extensively hydrophilic (blue) secondary hydroxyl face, or alternately, through the smaller cone opening (right) revealing the surface areas above the 6-CH2OH groups to be distinctly hydrophobic (yellow). The side-view MLPs (lower entries), in closed form and bisected with a ball-and-stick model insert, are oriented with the 2-OH/3-OH side (larger opening of the torus) pointing upward; they clearly expose the distribution of hydrophilic (blue) and hydrophobic (yellow) surface regions outside and inside the cavity. For further comments see F. W. Lichtenthaler and S. Immel, J. Inclusion Phenom. Mol. Recognit. Chem. 1996, 25, 3-16, or pp. 3-16 of this volume.

© Copyright PD Dr. S. Immel